PZL-A - CAS 3068830-89-4

PZL-A, an activator of mtDNA synthesis, restored the function and activity of the most common POLγ mutant variant and activated mtDNA synthesis in the cells of pediatric patients with fatal diseases, thereby enhancing the oxidative phosphorylation mechanism and the biogenesis of cellular respiration, and can be used to treat progressive diseases associated with mtDNA depletion.

OXPHOS, DNA/RNA Synthesis, Mitochondrial Metabolism

Apoptosis, Cell Cycle/Checkpoint, Metabolism, DNA Damage/DNA Repair

3068737

>99.99%

C19H17ClN4O2

368.82

N(C(NC1=NN(C=C1)C2=CC=CC=C2)=O)[C@@H]3C=4C(OCC3)=C(Cl)C=CC4

-20°C

Ice Packs

Small Compound