QL-1200186 - CAS 2848664-42-4

QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following interleukin-12 (IL-12) stimulation and markedly improves skin lesions in a psoriatic mouse model [1].

JAK

JAK/STAT signaling, Stem Cells, Angiogenesis, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors

2848664-42-4

C26H27N7O3

485.54

O=C(NC)C1=CN=C2C=C1NC3=CC(=CC(C4=NN(C=C4)C)=C3OC)CCOCC5=NC(=CC=C5)N2

-20°C

Ice Packs

Small Compound