QO-58 - CAS 1259536-62-3

QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, dose-dependently activating Kv7 currents, enhancing native neuronal M currents, and causing a decrease in evoked action potentials. It has anti-nociceptive effects on inflammatory pain and can be used for neuronal excitability disorders.

Potassium Channel

Membrane transporter/Ion channel

1259471

0.9917

C18H8Cl2F4N4O

443.18

O=C1C=C(NC2=C(C=3C=CC=CC3)C(=NN12)C(F)(F)F)C=4C=C(F)C(Cl)=NC4Cl

-20°C

Ice Packs

Small Compound