QR-6401 - CAS 2845096-18-4

QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/D3, and 45 nM for CDK4/D1. It exhibits potent antitumor activity in the OVCAR3 ovarian cancer xenograft model, indicating its potential for use in cancer research [1].

CDK

Cell Cycle/Checkpoint

2845074

C19H23N5O3

369.42

O=C1OC2CC(C3=CC(NN3)=NC=4N=C(COC5CC(N1)C5)C=CC4)CC2

-20°C

Ice Packs

Small Compound