Quazinone - CAS 70018-51-8

Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties. It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM), increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner (10-300 μg/kg), decreases systolic and diastolic blood pressure, and inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.

Others, MAPK, PDE

Others, MAPK, Metabolism

69959

C11H10ClN3O

235.67

C[C@H]1N2C(NC=3C(C2)=C(Cl)C=CC3)=NC1=O

-20°C

Ice Packs

Small Compound