Quinacrine analog 34 - CAS 1411646-44-0

Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM) . Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.

Others, Autophagy

Others, Autophagy

1411602

C20H27ClN4

358.91

N(CCN1CCN(C)CC1)C=2C=3C(N=C4C2CCCC4)=CC(Cl)=CC3

-20°C

Ice Packs

Small Compound