Quisinostat dihydrochloride - CAS 875320-31-3

Quisinostat dihydrochloride (JNJ26854165 (Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.

Apoptosis, Autophagy, HDAC

Chromatin/Epigenetic, Autophagy, DNA Damage/DNA Repair, Apoptosis

875286

0.985

C21H28Cl2N6O2

467.39

Cl.Cl.Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12

-20°C

Ice Packs

Small Compound