Quorum sensing-IN-9 - CAS 3063543-24-5

Quorum sensing-IN-9 (Compound 7d) inhibits quorum sensing in Pseudomonas aeruginosa by binding to the PqsR protein. It suppresses the expression of quorum sensing system-related genes lasB, rhlA, and pqsA, thereby preventing the production of virulence factors elastase, pyocyanin, and rhamnolipid. Quorum sensing-IN-9 disrupts the motility of P. aeruginosa, inhibits biofilm formation, and reduces the bacterium's virulence and pathogenicity. Additionally, it exhibits anti-infective activity in the Galleria mellonella larval model.

Antibacterial

Microbiology/Virology

3063514

C9H10OS2

198.305

OC1=CC=C(SSCC=C)C=C1

-20°C

Ice Packs

Small Compound