QWF - CAS 126088-82-2

Tripeptide substance P (SP) antagonist (IC50 = 90 μM) . Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.

Neurokinin receptor

GPCR/G Protein, Neuroscience

126004

C38H43N5O8

697.78

C([C@H](C(N[C@@H](CC1=CC=CC=C1)C(OCC2=CC=CC=C2)=O)=O)NC([C@@H](NC(OC(C)(C)C)=O)CCC(N)=O)=O)C=3C=4C(N(C=O)C3)=CC=CC4

-20°C

Ice Packs

Peptide