R-1663 - CAS 865451-66-7

R-1663 is a factor Xa inhibitor. R-1663 prolonged clotting times, inhibited thrombin generation (peak height and endogenous thrombin potential [ETP]) and anti-factor Xa activity in a concentration-dependent manner without increasing bleeding time. Pharmacodynamic parameters were strongly correlated to R-1663 plasma concentrations. The inhibition was more pronounced on peak height (IC50 = 194 ng/ml) than on ETP (2790 ng/ml) .

Others, Endogenous Metabolite

Metabolism, Others

865378

C24H21ClF3N5O3

519.9

C(NC1=C(F)C=C(C=C1)N2C(=O)C=CC=C2)(=O)[C@@H]3[C@@H](C(NC4=CC=C(Cl)C=N4)=O)CN(CC(F)F)C3

-20°C

Ice Packs

Small Compound