(R) -Afatinib - CAS 439081-17-1

(R) -Afatinib ((R) -BIBW 2992), an isomer of Afatinib, is a potent, orally administered, irreversible inhibitor targeting the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFR wt, 0.4 nM for EGFR L858R, 10 nM for EGFR L858R/T790M, and 14 nM for HER2, holding potential for research into esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC), and gastric cancer [1].

C-Met/HGFR, EGFR, p38 MAPK, Others

Tyrosine Kinase/Adaptors, Others, MAPK, JAK/STAT signaling, Angiogenesis

439063

C24H25ClFN5O3

485.94

N(C=1C2=C(C=C(O[C@@H]3CCOC3)C(NC(C=CCN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

-20°C

Ice Packs

Small Compound