(R) -AS-1 - CAS 2506367-95-7

(R) -AS-1 is a selective positive allosteric modulator of excitatory amino acid transporter 2 (EAAT2), with an EC50 of 11 nM. At doses of 60 and 90 mg/kg, (R) -AS-1 enhances spontaneous locomotor activity in mice. It demonstrates anticonvulsant properties in mouse seizure models induced by maximal electroshock (MES), pentylenetetrazole (PTZ), or electric current stimulation (32 or 44 mA), with ED50 values of 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively. This compound is applicable in neurological disease research.

Others, transporter

Metabolism, Others

2506265

C14H16N2O3

260.29

[C@H](C(NCC1=CC=CC=C1)=O)(C)N2C(=O)CCC2=O

-20°C

Ice Packs

Small Compound