(R) -Elagolix - CAS 834153-87-6

(R) -Elagolix (NBI-56418) is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a dose-dependent suppression of ovarian estrogen production, that is, from partial suppression at lower doses to full suppression at higher doses.

GNRH Receptor

GPCR/G Protein

834060

0.9908

C32H30F5N3O5

631.59

[H][C@@](Cn1c(=O)c(c(C)n(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1cccc(OC)c1F)(NCCCC(O)=O)c1ccccc1

-20°C

Ice Packs

Small Compound