(R) -KMH-233 - CAS 2994330-89-9

(R) -KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.

ASCT

Membrane transporter/Ion channel

2994330-89-9

C32H25N7O5

587.58

N(C(=O)C1=CC(C[C@H](C(O)=O)N)=CC=C1)C=2N3C(C(C#N)=C(C2C#N)C4=CC=C(OCC(NC)=O)C=C4)=NC=5C3=CC=CC5

-20°C

Ice Packs

Inhibitors & Agonists