(R) - (+) -O-Demethylbuchenavianine - CAS 1364123-68-1

(R) - (+) -O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, >10 μM, >10 μM, and >10 μM, respectively.

CDK, DYRK, GSK-3

Cell Cycle/Checkpoint, Stem Cells, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling

1364123-68-1

C21H21NO4

351.4

OC=1C(=C2C(C(=O)C=C(O2)C3=CC=CC=C3)=C(O)C1)[C@@H]4N(C)CCCC4

-20°C

Ice Packs

Small Compound