(R) -STU104-d6 - CAS 3063042-81-6

(R) -STU104-d6 is a deuterium-labeled variant of (R) -STU104. This compound acts as a potent and orally active inhibitor of the interaction between TAK1 and MKK3 proteins, exhibiting IC50 values of 0.58 μM for TNF-α and 4.0 μM for MKK3 phosphorylation. By binding to MKK3, (R) -STU104 hinders TAK1's ability to phosphorylate MKK3, thereby disrupting the TAK1/MKK3/p38/MnK1/MK2/elF4E signaling pathway. It is utilized in research related to ulcerative colitis.

P38 MAPK

MAPK

3062955

C18H182D6O4

304.37

O(C([2H])([2H])[2H])C1=C2[C@H](CC(=O)C2=CC(OC([2H])([2H])[2H])=C1)C3=CC=C(OC)C=C3

-20°C

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