(R) -Vorbipiprant - CAS 2502965-92-4

(R) -Vorbipiprant ((R) -CR6086) is an orally effective antagonist of the prostaglandin E2 receptor 4 (EP4), demonstrating a Ki of 16.6 nM for human EP4. It inhibits the production of cAMP induced by PGE2, with an IC50 of 22 nM. Additionally, (R) -Vorbipiprant exhibits immunomodulatory and antiangiogenic activities, having shown potential to alleviate collagen-induced arthritis in mice.

Prostaglandin Receptor

Immunology/Inflammation, GPCR/G Protein

2502965-92-4

C26H27F3N2O3

472.5

N(C(=O)[C@@H]1N(CC2=CC=C(C(F)(F)F)C=C2)CCC3(C1)CC3)C4(CC4)C5=CC=C(C(O)=O)C=C5

-20°C

Ice Packs

Small Compound