RA375 - CAS 2649154-57-2

RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increased activity to nitro ring substituents and the inclusion of a chloroacetamide warhead.

ROS, Reactive Oxygen Species, Apoptosis, Proteasome

Immunology/Inflammation, NF-κB, Proteases/Proteasome, Metabolism, Apoptosis, Ubiquitination

2649095

0.9956

C30H25ClN4O7

588.99

O=C(CCl)N[C@H](C(N1C/C(C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)=O)=C\C3=CC=C([N+]([O-])=O)C=C3)=O)CC4=CC=CC=C4

-20°C

Ice Packs

Small Compound