(Rac) -BDA-366 - CAS 142645-19-0

(Rac) -BDA-366 (example 2) is the racemate of BDA-366, a potent Bcl-2 antagonist with a Ki of 3.3 nM. It shows high affinity and selectivity for the Bcl-2-BH4 domain. BDA-366 induces a conformational change in Bcl-2, neutralizing its anti-apoptotic function and converting Bcl-2 from a survival molecule into a cell death inducer. Additionally, BDA-366 can inhibit the growth of lung cancer cells.

Bcl-2 Family

Apoptosis

142626

C24H29N3O4

423.5

O=C1C=2C=CC=CC2C(=O)C=3C(=CC=C(NCC(O)CN(CC)CC)C13)NCC4OC4

-20°C

Ice Packs

Small Compound