Rac-Belinostat - CAS 414864-00-9

Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.

Autophagy, HDAC

Autophagy, Chromatin/Epigenetic, DNA Damage/DNA Repair

414864-00-9

0.9996

C15H14N2O4S

318.35

ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1

-20°C

Ice Packs

Small Compound