(Rac) -EBET-1055 - CAS 3031540-65-2

(R, R) -VRT-534 is the enantiomer of VRT-534. EBET-1055 is a bromodomain and extra-terminal (BET) PROTAC degrader. It effectively inhibits the growth of pancreatic ductal adenocarcinoma (PDAC) . Additionally, EBET-1055 modulates cancer-associated fibroblast (CAF) activity, increasing the activity of all reporter genes in organoid co-cultures.

PROTACs, Epigenetic Reader Domain

Chromatin/Epigenetic, PROTAC

3031540-65-2

C51H54N8O9

923.02

O=C1C=2C=CC=C(OCC(=O)N3CCN(CC3)CC4CCN(C=5N=C6C=CC(=CC6=C(N5)C(OC7CC7)(C=8C=CC=CC8)CO)C=9C=C(C(=O)N(C9)C)C)CC4)C2C(=O)N1C%10C(=O)NC(=O)CC%10

-20°C

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