(Rac) -PROTAC PARP/EGFR ligand 1 - CAS 2935073-36-0

(Rac) -PROTAC PARP/EGFR ligand 1 is a compound that includes ligands for target proteins PARP and EGFR, along with a PROTAC linker that recruits E3 ligases such as VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC DP-C-4, a dual CRBN-based PROTAC designed for the concurrent degradation of EGFR and PARP.

Target Protein Ligand-Linker Conjugate

PROTAC

2935037

C53H56ClF2N9O8

1020.52

O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CCN(C(=O)CCCCCNC(=O)C(NC(=O)CCCCCOC5=CC=6C(=NC=NC6NC7=CC=C(F)C(Cl)=C7)C=C5OC)COCC#C)CC4

-20°C

Ice Packs

PROTAC