Racecadotril-d5 - CAS 1246815-11-1

Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan. In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-induced diarrhea. Formulations containing racecadotril have been used in the treatment of acute diarrhea.

Neprilysin

Metabolism

1246803

C21H18D5NO4S

390.51

C(CC1=CC=CC=C1)(C(NCC(OCC2=C(C(=C(C(=C2[2H])[2H])[2H])[2H])[2H])=O)=O)CSC(C)=O

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