Ran-IN-1 - CAS 2301869-11-2

Ran-IN-1 (Compound M36) is an orally active and selective inhibitor of Ran GTPase. It binds allosterically with high specificity to the switch II pocket of GDP-bound Ran (RanGDP), stabilizing its inactive state and reducing the formation of active Ran-GTP. Ran-IN-1 induces apoptosis in epithelial ovarian cancer (EOC) cells and inhibits DNA repair pathways such as homologous recombination (HR) and non-homologous end joining (NHEJ) . This compound shows potential for research in epithelial ovarian cancer, particularly in high-grade serous carcinoma.

GTPase, Apoptosis

Apoptosis, GPCR/G Protein

2301856

C27H26F3NO4S

517.56

O(CC1=CC=C(F)C=C1)[C@H]2[C@@H](OCC3=CC=C(F)C=C3)[C@H](C(N)=S)O[C@@H]2COCC4=CC=C(F)C=C4

-20°C

Ice Packs

Small Compound