RAS inhibitor Abd-7 - CAS 2351843-48-4

RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].

Kras, Others, Ras

GPCR/G Protein, MAPK, Others

2351791

C23H25N3O3

391.46

COc1nc(ccc1Nc1ccc(CN(C)C)cc1)-c1cccc2OCCOc12

-20°C

Ice Packs

Small Compound