Rasagiline-13C3 (mesylate) - CAS 1391052-18-8

Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme) .1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme) . It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo (ED50= 0.1 mg/kg) .1It reduces cerebral edema in a mouse model of traumatic brain injury.2Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson's disease.3Formulations containing rasagiline have been used in the treatment of Parkinson's disease.

Apoptosis, Autophagy, Monoamine Oxidase

Neuroscience, Autophagy, Apoptosis

1391026

C13H17NO3S

270.32

CS(O)(=O)=O.[13CH]#[13C][13CH2]N[C@@H]1CCc2ccccc12

-20°C

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