Rec 15/2615 (hydrochloride) - CAS 1782573-48-1

Rec 15/2615 is an antagonist of α1B-adrenergic receptors (α1B-ARs; Ki = 0.45 nM for the recombinant human receptor) .1 It selectively inhibits α1B-ARs over α1A-, α1D-, and α1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively) . Rec 15/2615 inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (Kis = 100 and 316.2 nM, respectively), as well as reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (Ki = 50 nM) .2 It decreases diastolic blood pressure (ED25 = 183 μg/kg, i.v.) and increases intracavernous pressure in anesthetized dogs when administered intracavernously at doses ranging from 30 and 1,000 μg/kg.1,2

Others

Others

1782524

C26H35Cl2N5O5

568.49

O=C(COC1=C(C(C)C)C=CC=C1OC)N2CCN(CC2)C3=NC4=C(C=C(C(OC)=C4)OC)C(N)=N3.Cl.Cl

-20°C

Ice Packs

Small Compound