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Regorafenib monohydrate - CAS 1019206-88-2

Regorafenib monohydrate - CAS 1019206-88-2

MF-0000306-01

$32.42 USD
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Product Details

  • Bioactivity

    Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF (V600E) respectively.

  • Target

    C-Kit, PDGFR, Tie-2, Autophagy, Raf, FGFR, c-RET, VEGFR

  • Related Pathways

    MAPK, Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis, Autophagy

  • CAS Number

    1019206-88-2

  • Purity

    0.9969

  • Molecular Formula

    C21H17ClF4N4O4

  • Molecular Weight

    500.83

  • SMILES

    O.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound