RET-IN-13 - CAS 2684258-54-4

RET-IN-13, a quinoline-based compound, effectively inhibits the RET kinase, demonstrating IC50 values of 0.5 nM for RET (WT) and 0.9 nM for RET (V804M) . It holds promise for research into tumors and intestinal diseases associated with abnormal RET activation.

C-RET, Others

Apoptosis, Others, Tyrosine Kinase/Adaptors

2684200

C32H33F4N5O3

611.63

O(C)C1=CC2=C(C=C1OC)N=CC(=C2)C3=CC=C(CC(NC4=CC(C(F)(F)F)=C(CN5CCN(CC)CC5)C=C4F)=O)C=N3

-20°C

Ice Packs

Small Compound