RET-IN-14 - CAS 2755843-62-8

RET-IN-14 is a potent inhibitor of RET, capable of acting on RET (WT) (IC50 < 0.51 nM), RET (G810R) (IC50: 9.3 nM), RET (V804M) (IC50: 1.3 nM), BTK (C481S) (IC50: 9.2 nM) and BTK (C481S) (IC50 : 15 nM) . RET-IN-14 exhibits potential for tumor studies.

C-RET, BTK, Others

Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis, Others

2755773

C24H23FN8O4

506.49

NC=1N2C3=C(C=N2)C(=O)NC[C@H](C)OC=4C(CN=C(N3)C1C5=CC=C(NC(OC)=O)C=C5)=CC(F)=CN4

-20°C

Ice Packs

Small Compound