RET-IN-16 - CAS 2259657-48-0

RET-IN-16 is a potent, selective inhibitor of RET, exhibiting IC50 values of 3.98 nM for RET (WT), 8.42 nM for RET (M918T), 15.05 nM for RET (V804L), 7.86 nM for RET (V804M), 5.43 nM for RET-CCDC6, and 8.86 nM for RET-KIF5B, indicating its high efficacy across different RET mutations. It possesses anticancer properties.

Others, c-RET

Apoptosis, Others, Tyrosine Kinase/Adaptors

2259609

C31H29F3N8O2

602.61

O(C1=C2C(=NC(=N1)C=3C=CC=NC3)NN=C2)C4=CC(C(NC5=CC(C(F)(F)F)=C(CN6CCN(C)CC6)C=C5)=O)=CC=C4C

-20°C

Ice Packs

Small Compound