RET-IN-22 - CAS 2918281-79-3

RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-V804M. It demonstrates a highly selective inhibition profile across a broad spectrum of kinases, with notable specificity over EGFR and VEGFR2, and is implicated in exerting anticancer effects [1].

C-RET, Others

Others, Apoptosis, Tyrosine Kinase/Adaptors

2918199

C29H31F3N6O4

584.59

N(C(NC=1C=C(C(C(F)(F)F)(C)C)ON1)=O)C2=CC=C(C=3C=C(NN3)C4=CC=C(OCCN5CCOCC5)C=C4)C=C2

-20°C

Ice Packs

Small Compound