RET-IN-4 - CAS 2436473-55-9

RET-IN-4 is a highly effective and specific RET inhibitor that can be administered orally. It demonstrates remarkable potency, with IC50 values of 1.29 nM, 1.97 nM, and 0.99 nM for inhibiting RET variants including RET (WT), RET (V804M), and RET (M918T), respectively. Moreover, RET-IN-4 exhibits superior selectivity towards kinases JAK2 (IC50 of 4.4 nM) and FLT3 (IC50 of 30.8 nM) . Additionally, RET-IN-4 possesses pronounced anticancer properties.

Others, c-RET

Apoptosis, Tyrosine Kinase/Adaptors, Others

2436409

C27H31FN10O2

546.611

C[C@H](N1CCOC2(CCN(CC2)c2nc(C)cc(Nc3cc(C)[nH]n3)n2)C1=O)c1ccc(nc1)-n1cc(F)cn1

-20°C

Ice Packs

Small Compound