RET/TRKA-IN-1 - CAS 3048634-52-9

RET/TRKA-IN-1 (Compound 13) is a dual inhibitor targeting RET with an IC50 of 0.375 μM and TRKA. It reduces cell viability of LC-2 and KM12, with GI50 values of 0.72 and 0.25 μM respectively. RET/TRKA-IN-1 also induces cell cycle arrest at the G1 phase.

C-RET, Trk receptor

Apoptosis, Tyrosine Kinase/Adaptors

3048573

C30H31N9O

533.63

O=C(NC1=CC(=NN1C)C(C)(C)C)CC2=CC=C(C=C2)NC=3N=CN=C4NC5=CC(=CC=C5C34)C=6C=NN(C6)C

-20°C

Ice Packs

Small Compound