RG-12525 - CAS 120128-20-3

RG-12525 (NID 525) is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of guinea pig thin-walled bands, with IC50 values of 2.6 nM, 2.5 nM, and 7 nM, respectively.RG-12525 inhibits CYP3A4, with a Ki value of 0.5 μM. RG-12525 is a novel and potent PPAR-γ agonist (IC50 value of about 60 nM) with species specificity for the study of asthma.

PPAR, Cytochromes P450, Leukotriene Receptor

Metabolism, GPCR/G Protein, DNA Damage/DNA Repair

120105

0.9677

C25H21N5O2

423.47

N1=NNC(=N1)CC=2C=CC=CC2COC3=CC=C(OCC4=NC=5C=CC=CC5C=C4)C=C3

-20°C

Ice Packs

Small Compound