RG7112D - CAS 2360561-90-4

RG7112D is a potent MDM2 inhibitor, effectively inhibiting MDM2-p53 and VHL-HIF1α interactions with IC50 values of 11 nM and >10000 nM, respectively, as determined by HTRF binding assays. It couples with VHL-Amine via an amide bond to form the bifunctional molecule YX-02-030. YX-02-030 acts as an MDM2-PROTAC, efficiently blocking MDM2-p53 binding (HTRF IC50= 63 nM) . Additionally, RG7112D stabilizes MDM2 protein and enhances p53 protein levels.

MDM-2/p53

Apoptosis

2360561-90-4

C36H42Cl2N4O4

665.65

C[C@@]1(N(C(=O)N2CCN(CC(O)=O)CC2)C(=N[C@@]1(C)C3=CC=C(Cl)C=C3)C4=C(OCC)C=C(C(C)(C)C)C=C4)C5=CC=C(Cl)C=C5

-20°C

Ice Packs

PROTAC