RGB-286638 free base - CAS 784210-88-4

RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.

GSK-3, JAK, MEK, CDK

Cell Cycle/Checkpoint, Chromatin/Epigenetic, MAPK, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Stem Cells

784118

0.9991

C29H35N7O4

545.63

COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1

-20°C

Ice Packs

Small Compound