RGN6024 - CAS 3055038-20-2

RGN6024 is an orally active, reversible small molecule that can penetrate the blood-brain barrier and acts as a microtubule (tubulin) destabilizer. It inhibits microtubule polymerization in both biochemical and cellular assays. RGN6024 binds to the colchicine-binding site of β-tubulin with affinity constants of Kd= 6.7 μM (SPR) and Kd= 7.4 μM (tryptophan assay), inducing G2/M phase arrest in glioblastoma (GB) cells. The compound remains effective in cells overexpressing βIII-tubulin. Additionally, RGN6024 is able to suppress tumor growth in glioblastoma (GB) xenograft mouse models. This compound is applicable for research in glioblastoma (GB) .

Microtubule Associated

Cytoskeletal Signaling

3055016

C18H21N5O4S

403.46

O=C(NC1=NC=C(OC2=CN=C(N=C2)N3CCOCC3)S1)C45CC(OC)(C4)C5

-20°C

Ice Packs

Small Compound