Rhynchophylline - CAS 76-66-4

1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in cultured neurons in vitro. 3. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.

NF-κB, Calcium Channel

Membrane transporter/Ion channel, Metabolism, NF-κB

76-66-4

0.9998

C22H28N2O4

384.47

CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C(=O)Nc1ccccc31

-20°C

Ice Packs

Natural Product