Rigosertib - CAS 592542-59-1

Rigosertib (ON-01910) is a selective, non-ATP-competitive PLK1 inhibitor (IC50: 9 nM) and multi-kinase inhibitor. As a selective anti-cancer agent, Rigosertib induces apoptosis by inhibiting the PI3 kinase/Akt pathway, promotes histone H2AX phosphorylation, and induces G2/M arrest in the cell cycle.

PI3K, PLK, FLT, Apoptosis, PDGFR, Src, CDK, Bcr-Abl

Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling, Apoptosis, Angiogenesis, Cytoskeletal Signaling

592542-59-1

0.9953

C21H25NO8S

451.49

C(=C/S(CC1=CC(NCC(O)=O)=C(OC)C=C1)(=O)=O)\C2=C(OC)C=C(OC)C=C2OC

-20°C

Ice Packs

Small Compound