RIP1 kinase inhibitor 8 - CAS 2226735-54-0

RIP1 Kinase Inhibitor 8 (Compound 77), a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor, exhibits an IC50 of 20 nM and effectively prevents necrotic cell death. It also demonstrates a favorable pharmacokinetic profile across multiple species [1].

RIP kinase, Necroptosis

Apoptosis, NF-κB

2226681

C18H19F2N5O2

375.37

C(=O)(N1[C@@H](CC=N1)C2=CC(F)=CC(F)=C2)C3CCN(CC3)C4=NN=C(C)O4

-20°C

Ice Packs

Small Compound