RIP2 Kinase Inhibitor 4 - CAS 2126803-41-4

RIP2 Kinase Inhibitor 4 is a highly potent and selective RIPK2 PROTAC compound that efficiently degrades RIPK2 (pIC50 value of 8) and effectively inhibits the release of TNF-α.

Others, PROTACs, RIP kinase

NF-κB, Others, Apoptosis, PROTAC

2126758

C50H66F2N14O7S

1045.23

CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)Nc1c(F)cccc1F)NC(=O)c1cnc(cn1)N1CCN(CCCOc2cc3ncnc(Nc4n[nH]c(C)c4C)c3cc2S(=O)(=O)C(C)(C)C)CC1)C(C)(C)C |@@:70|

-20°C

Ice Packs

PROTAC