RIPK1-IN-16 - CAS 2561431-77-2

RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo, protecting mice from TNF-induced systemic inflammatory response syndrome and sepsis [1].

RIP kinase

NF-κB, Apoptosis

2561431-77-2

C20H19N5O2S

393.46

CN1C=2C(OC[C@H](NC(=O)C=3NC(CC4=CC=CC=C4)=NN3)C1=S)=CC=CC2

-20°C

Ice Packs

Small Compound