RIPK1-IN-17 - CAS 3033385-59-7

RIPK1-IN-17 is a dual inhibitor of RIPK1 and RIPK3 that specifically inhibits necrosis by inhibiting phosphorylation of RIPK1, RIPK3 and MLKL, protecting mice from hypothermia and death in a tnf-induced inflammation model.

RIP kinase

Apoptosis, NF-κB

3033385-59-7

0.9522

C26H19F4N3O3S

529.51

FC1=C(NC(CC2=CC=CC(OC(F)(F)F)=C2)=O)C=C(C3=CC=C(N=C(NC(C4CC4)=O)S5)C5=C3)C=C1

-20°C

Ice Packs

Small Compound