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RIPK1-IN-20 - CAS 3026543-19-8

RIPK1-IN-20 - CAS 3026543-19-8

MF-0116400-01

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Product Details

  • Bioactivity

    RIPK1-IN-20 has strong RIPK1 kinase inhibitory activity with an IC50 value of 59.8 nM. It can block TNFα-induced necroptosis in both human and mouse cells, with an EC50 ranging from 1.06 to 4.58 nM.

  • Target

    Necroptosis, RIP kinase

  • Related Pathways

    Apoptosis, NF-κB

  • CAS Number

    3026516

  • Molecular Formula

    C28H26F3N5O4

  • Molecular Weight

    553.53

  • SMILES

    O=C1NN=C(N)C=2C(=CN(C12)CC3(C)COC3)C=4C=CC5=C(C4)CCN5C(=O)CC=6C=CC=C(OC(F)(F)F)C6

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound