RIPK2-IN-8 - CAS 3036254-29-9

RIPK2-IN-8 is an orally active and highly selective RIPK2 inhibitor with an IC50 of 11 nM. It exhibits greater selectivity for RIPK2 over RIPK1 (IC50 > 30,000 nM) and has moderate inhibitory effects on RIPK3 (IC50 = 44.61 nM) . RIPK2-IN-8 exerts anti-inflammatory effects by inhibiting the NOD2-RIPK2 signaling pathway and the expression of inflammatory cytokines IL-6 and TNFα. Additionally, in models of acute liver injury (ALI), RIPK2-IN-8 demonstrates both anti-inflammatory and hepatoprotective effects, making it useful for ALI research.

Interleukin, NF-κB, p38 MAPK, RIP kinase

Apoptosis, MAPK, NF-κB, Immunology/Inflammation

3036216

C22H20FN5OS2

453.56

O=C(NC1CC=C(C=2SC3=C(N=CN=C3NC4=CC=5N=CSC5C=C4F)C2)CC1)CC

-20°C

Ice Packs

Small Compound