Rizatriptan-d6 benzoate salt - CAS 1216984-85-8

Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin receptor subtypes 5-HT1B and 5-HT1D. It is selective for 5-HT1B and 5-HT1D receptors over 5-HT1A receptors. Rizatriptan induces vasoconstriction in isolated human middle meningeal arteries. In vivo, rizatriptan reduces head grooming, the number of oculotemporal strokes, eye blinking, and one-eye closures in a Cacna1a mutant transgenic mouse model of migraine. Formulations containing rizatriptan have been used in the treatment of migraine.

5-HT Receptor

GPCR/G Protein, Neuroscience

1216891

C22H19D6N5O2

397.5116

OC(=O)c1ccccc1.[2H]C([2H])([2H])N(CCc1c[nH]c2ccc(Cn3cncn3)cc12)C([2H])([2H])[2H]

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