RJG-2036 - CAS 2851993-73-0

RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2) with an IC50 of 100 nM. It effectively inhibits NADPH-dependent reduction reactions, significantly reducing the secretion of inflammatory factors such as TNF-α and the release of various pro-inflammatory eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 shows promise for research in inflammatory diseases.

Prostaglandin Receptor

Immunology/Inflammation, GPCR/G Protein

2851920

C20H21N5O4S

427.48

O=C(C1=CC=CC(=C1)S(=O)(=O)N2N=CN=C2)N3CCN(C=4C=CC=CC4OC)CC3

-20°C

Ice Packs

Small Compound