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Molfinity

RK-0080552 - CAS 313527-11-6

RK-0080552 - CAS 313527-11-6

MF-0114960-01

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Product Details

  • Bioactivity

    RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t (4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.

  • Target

    Histone Methyltransferase

  • Related Pathways

    Chromatin/Epigenetic

  • CAS Number

    313510

  • Molecular Formula

    C12H6N6O2

  • Molecular Weight

    266.215

  • SMILES

    O=C1C=2N=NC(=NC2C=3C=CC=CC13)C4=NON=C4N

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound