RMC-4998 - CAS 2642037-07-6

RMC-4998 is an orally available KRASG12C mutant inhibitor that targets the active or GTP-bound state of the KRASG12C mutant and binds to intracellular CYPA to form a triple complex to inhibit the ERK signaling pathway and induce apoptosis, which is of great significance for tumor research.

PI3K, Kras, ERK, mTOR, Ras, Apoptosis

GPCR/G Protein, MAPK, Apoptosis, PI3K/Akt/mTOR signaling

2642037-07-6

0.9911

C57H74N8O7

983.25

O=C(N1CC[C@@]2(C1)C(N(C(C(C)C)C(NC3C(N4N[C@@H](CCC4)C(OCC(C)(CC5=C(C6=C([C@@H](C)OC)N=CC=C6)N(CC)C7=CC=C(C8=CC(C3)=CC=C8)C=C57)C)=O)=O)=O)CC2)=O)C#CC(C)(C)N(C)C

-20°C

Ice Packs

Small Compound